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Products Details
Product Description
– Dehydroaltenusin is a small molecule selective inhibitor of eukaryotic DNA polymerase α, a type of antibiotic produced by a fungus with an IC50 value of 0.68 μM. The inhibitory mode of action of dehydroaltenusin against mammalian pol α activity is competitive with respect to the DNA template primer (Ki=0.23 µM) and non-competitive with respect to the 2′-deoxyribonucleoside 5′-triphosphate substrate (Ki=0.18 µM)[1]. Dehydroaltenusin arrests the cancer cell cycle at the S-phase and triggers apoptosis[1]. Dehydroaltenusin possesses anti-tumor activity against human adenocarcinoma tumor in vivo[1].
Web ID
– HY-100513A
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C15H12O6
References
– [1]Mizushina Y, et al. Dehydroaltenusin is a specific inhibitor of mammalian DNA polymerase α. Expert Opin Investig Drugs. 2011 Nov;20(11):1523-34.
CAS Number
– 31186-13-7
Molecular Weight
– 288.25
SMILES
– O=C(C(O)=C1)C=C(C2=CC(OC)=CC(O)=C23)[C@@]1(C)OC3=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Antibiotic;Apoptosis;DNA/RNA Synthesis
Pathway
– Anti-infection;Apoptosis;Cell Cycle/DNA Damage
Product type
– Natural Products
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