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Products Details
Product Description
– Debio 0617B, a multi-kinase inhibitor, reduces maintenance and self-renewal of primary human AML CD34+ stem/progenitor cells. Debio 0617B has a unique profile targeting key kinases upstream of STAT3/STAT5 signaling such as JAK, SRC, ABL, and class III/V receptor tyrosine kinases (TKs). Debio 0617B has documented efficacy in STAT3-driven solid tumors[1].
Web ID
– HY-108417
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C28H23ClF3N7O2
References
– [1]Maximilien Murone, et al. The Multi-kinase Inhibitor Debio 0617B Reduces Maintenance and Self-renewal of Primary Human AML CD34<sup>+</sup> Stem/Progenitor Cells. Mol Cancer Ther. 2017 Aug;16(8):1497-1510.
CAS Number
– 1332329-27-7
Molecular Weight
– 581.98
SMILES
– O=C(C1=NC=CC(C(F)(F)F)=C1)NC2=CC=C(Cl)C(N3CCC4=NC(NC5=CC=C(C(NC)=O)C=C5)=NC=C4C3)=C2
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Bcr-Abl;JAK;STAT
Pathway
– Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
