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Products Details
Product Description
– DDO3711, a PP5-recruiting phosphatase recruitment chimeras (PHORCs), is formed by connecting a small molecular apoptosis signal-regulated kinase 1 (ASK1) inhibitor to a PP5 activator through a chemical linker. DDO3711 specifically inhibits ASK1 (IC50 =164.1 nM) not ASK2 (IC50>20 μM). DDO3711 significantly dephosphorylates p-ASK1T838 by recruiting PP5 and shows the ASK1-dependent antiproliferative activity. DDO3711 has anti-cancer activity and has the potential for abnormally phosphorylated oncoproteins research[1].
Web ID
– HY-152247
Shipping
– Room temperature
Molecular Formula
– C42H41N9O6
References
– [1]Qiuyue Zhang, et al. Protein Phosphatase 5-Recruiting Chimeras for Accelerating Apoptosis-Signal-Regulated Kinase 1 Dephosphorylation with Antiproliferative Activity. J Am Chem Soc. 2022 Dec 22.
CAS Number
– 2673364-10-6
Molecular Weight
– 767.83
SMILES
– COC1=CC=C(C=C1OC)C2=NC(CC3=CC=C(C=C3)C(NCCCCCCNC(C4=CC=C(C=C4)C(NC5=CN6C=C(C=CC6=N5)N7C=CN=C7)=O)=O)=O)=NO2
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– MAP3K
Isoform
– ASK2;MAP3K5/ASK1
Pathway
– MAPK/ERK Pathway
Product type
– Reference compound
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