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ddATP (trisodium)
$980 – $1,650
Products Details
Product Description
– ddATP (2′,3′-Dideoxyadenosine 5′-triphosphate) trisodium, an active metabolite of 2′,3′-dideoxyinosine, is a chain-elongating inhibitor of DNA polymerase. ddATP trisodium can be used for Sanger method for DNA sequencing and research of virus infection[1][2][4].
Web ID
– HY-128036B
Storage Temperature
– Solution, -20°C, 2 years
Shipping
– Blue Ice
Applications
– COVID-19-anti-virus
Molecular Formula
– C10H13N5Na3O11P3
References
– [1]van der Vliet PC, et al. Role of DNA polymerase gamma in adenovirus DNA replication. Mechanism of inhibition by 2′,3′-dideoxynucleoside 5′-triphosphates. Biochemistry. 1981 Apr 28;20(9):2628-32. |[2]Xu Lan, et al. Simultaneous determination of 2 ,3 -dideoxyinosine and the active metabolite, 2 ,3 -dideoxyadenosine-5 -triphosphate in human peripheral-blood mononuclear cell by HPLC–MS/MS and the application to cell pharmacokinetics. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Oct 1;1002:337-42. |[3]Jun-Yu Ma, et al. Double-strand breaks induce short-scale DNA replication and damage amplification in the fully grown mouse oocytes. Genetics. 2021 Jun 24;218(2):iyab054. |[4]C M Perry, et al. Didanosine. An update on its antiviral activity, pharmacokinetic properties and therapeutic efficacy in the management of HIV disease. Drugs. 1996 Dec;52(6):928-62. |[5]Hao Z, et al. Factors determining the activity of 2′,3′-dideoxynucleosides in suppressing human immunodeficiency virus in vitro. Mol Pharmacol. 1988 Oct;34(4):431-5.
CAS Number
– 72029-21-1
Molecular Weight
– 541.13
Compound Purity
– 98.0
SMILES
– NC1=NC=NC2=C1N=CN2[C@H](O3)CC[C@H]3COP(OP(OP(O)(O[Na])=O)(O[Na])=O)(O[Na])=O
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– 10 mM in H2O
Target
– DNA/RNA Synthesis;HIV
Pathway
– Anti-infection;Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
