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Products Details
Product Description
– DB07107 is a potent agent resistant T315I mutant Bcr-Abl tyrosine kinase inhibitor. DB07107 is also a potent Akt1 inhibitor with an IC50 value of 360 nM[1][2].
Web ID
– HY-123390
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C23H22N4O
References
– [1]Banavath HN, et al. Identification of novel tyrosine kinase inhibitors for drug resistant T315I mutant BCR-ABL: a virtual screening and molecular dynamics simulations study. Sci Rep. 2014 Nov 10;4:6948.|[2]Li Q, et al. Discovery of trans-3,4′-bispyridinylethylenes as potent and novel inhibitors of protein kinase B (PKB/Akt) for the treatment of cancer: Synthesis and biological evaluation. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1679-85.
CAS Number
– 552332-71-5
Molecular Weight
– 370.45
SMILES
– N[C@@H](COC1=CN=CC(/C=C/C2=CC=NC=C2)=C1)CC3=CNC4=C3C=CC=C4
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Akt;Bcr-Abl
Isoform
– Akt1
Pathway
– PI3K/Akt/mTOR;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
