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Darifenacin (hydrobromide)
$25 – $60
Products Details
Product Description
– Darifenacin hydrobromide (UK-88525 hydrobromide) is a selective M3 muscarinic receptor antagonist with a pKi of 8.9.
Web ID
– HY-A0012
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C28H31BrN2O2
Citations
– ACS Omega. 2020 Oct 12;5(41):26551-26561.|Eur J Pharmacol. 2011 Aug 1;663(1-3):74-9. |Br J Pharmacol. 2015 Dec;172(23):5619-33. |Oncotarget. 2016 Apr 5;7(14):18085-94. |Sci Rep. 2017 Jan 19;7:40802.
References
– [1]Hegde SS, et al. Functional role of M2 and M3 muscarinic receptors in the urinary bladder of rats in vitro and in vivo. Br J Pharmacol, 1997, 120(8), 1409-1418.|[2]Miller DW, et al. Evaluation of drug efflux transporter liabilities of darifenacin in cell culture models of the blood-brain and blood-ocular barriers. Neurourol Urodyn, 2011, 30(8), 1633-1638.|[3]Iijima K, et al. Effects of the M3 receptor selective muscarinic antagonist darifenacin on bladder afferent activity of the rat pelvic nerve. Eur Urol, 2007, 52(3), 842-847.
CAS Number
– 133099-07-7
Molecular Weight
– 507.46
Compound Purity
– 99.82
SMILES
– O=C(C(C1=CC=CC=C1)([C@@H]2CCN(CCC3=CC4=C(OCC4)C=C3)C2)C5=CC=CC=C5)N.Br
Clinical Information
– Launched
Research Area
– Neurological Disease; Cancer
Solubility
– DMSO : 33.33 mg/mL (ultrasonic)
Target
– mAChR
Isoform
– mAChR3
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
