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Darifenacin

Web ID

– HY-A0033

Storage Temperature

– -20°C, 3 years; 4°C, 2 years (Powder)

Shipping

– Room Temperature

Applications

– Neuroscience-Neuromodulation

Molecular Formula

– C28H30N2O2

Citations

– Br J Pharmacol. 2015 Dec;172(23):5619-33. |Oncotarget. 2016 Apr 5;7(14):18085-94. |Sci Rep. 2017 Jan 19;7:40802.|ACS Omega. 2020 Oct 12;5(41):26551-26561.|Eur J Pharmacol. 2011 Aug 1;663(1-3):74-9.

References

– [1]Hegde SS, et al. Functional role of M2 and M3 muscarinic receptors in the urinary bladder of rats in vitro and in vivo. Br J Pharmacol, 1997, 120(8), 1409-1418.|[2]Miller DW, et al. Evaluation of drug efflux transporter liabilities of darifenacin in cell culture models of the blood-brain and blood-ocular barriers. Neurourol Urodyn, 2011, 30(8), 1633-1638.|[3]Iijima K, et al. Effects of the M3 receptor selective muscarinic antagonist darifenacin on bladder afferent activity of the rat pelvic nerve. Eur Urol, 2007, 52(3), 842-847.|[4]Lu XZ, et al. Activation of M3 cholinoceptors attenuates vascular injury after ischaemia/reperfusion by inhibiting the Ca2+/calmodulin-dependent protein kinase II pathway. Br J Pharmacol. 2015 Dec;172(23):5619-33.|[5]Yu H, et al.Acetylcholine acts through M3 muscarinic receptor to activate the EGFR signaling and promotes gastric cancer cell proliferation. Sci Rep. 2017 Jan 19;7:40802.

CAS Number

– 133099-04-4

Molecular Weight

– 426.55

Compound Purity

– 97.38

SMILES

– O=C(N)C(C1=CC=CC=C1)([C@H]2CN(CCC3=CC=C(OCC4)C4=C3)CC2)C5=CC=CC=C5

Clinical Information

– Launched

Research Area

– Cancer; Neurological Disease

Solubility

– 10 mM in DMSO

Target

– mAChR

Isoform

– mAChR3

Pathway

– GPCR/G Protein;Neuronal Signaling

Product type

– Reference compound

Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.

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