Download Files:
Products Details
Product Description
– DAPT (GSI-IX) (GMP) is DAPT (HY-13027) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DAPT is a potent and orally active γ-secretase inhibitor[1][2].
Web ID
– HY-13027G
Shipping
– Room temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C23H26F2N2O4
References
– [1]Choi IY, et al. Concordant but Varied Phenotypes among Duchenne Muscular Dystrophy Patient-Specific Myoblasts Derived using a Human iPSC-Based Model. Cell Rep. 2016 Jun 7;15(10):2301-2312.|[2]Qi Y, et al. Combined small-molecule inhibition accelerates the derivation of functional cortical neurons from human pluripotent stem cells. Nat Biotechnol. 2017 Feb;35(2):154-163.
CAS Number
– 208255-80-5
Molecular Weight
– 432.46
SMILES
– FC1=CC(F)=CC(CC(N[C@H](C(N[C@H](C(OC(C)(C)C)=O)C2=CC=CC=C2)=O)C)=O)=C1
Clinical Information
– No Development Reported
Research Area
– Cancer; Inflammation/Immunology; Neurological Disease
Solubility
– 10 mM in DMSO
Target
– γ-secretase
Pathway
– Neuronal Signaling;Stem Cell/Wnt
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
