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Dapsone-d8
$150 – $800
Products Details
Product Description
– Dapsone-d8 is a deuterium labeled Dapsone. Dapsone is an orally active and blood-brain penetrant sulfonamide antibiotic with antibacterial, antigenic and anti-inflammatory activities[1]. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone can be used as an anticonvulsant and also in the research of skin and glioblastoma diseases[2][3][4][5].
Web ID
– HY-B0688S
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Metabolism-sugar/lipid metabolism
Molecular Formula
– C12H4D8N2O2S
References
– [1]Y I Zhu, et al. Dapsone and sulfones in dermatology: overview and update. J Am Acad Dermatol|[2]Dapsone. Drug.com|[3]D Voeller, et al. Interaction of Pneumocystis carinii dihydropteroate synthase with sulfonamides and diaminodiphenyl sulfone (dapsone).J Infect Dis. 1994 Feb;169(2):456-9.|[4]Esther Moreno, et al. Evaluation of Skin Permeation and Retention of Topical Dapsone in Murine Cutaneous Leishmaniasis Lesions.Pharmaceutics. 2019 Nov 13;11(11):607.|[5]Wozel G, et al. Dapsone in dermatology and beyond. Arch Dermatol Res. 2014 Mar;306(2):103-24. |[6]Noroozi N, et al. Protective Effects of Dapsone on Scopolamine-Induced Memory Impairment in Mice: Involvement of Nitric Oxide Pathway. Dement Geriatr Cogn Dis Extra. 2022 Mar 24;12(1):43-50.
CAS Number
– 557794-38-4
Molecular Weight
– 256.35
Compound Purity
– 98.0
SMILES
– NC1=C(C([2H])=C(C([2H])=C1[2H])S(C2=C(C([2H])=C(C([2H])=C2[2H])N)[2H])(=O)=O)[2H]
Clinical Information
– No Development Reported
Research Area
– Cancer; Infection; Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Antibiotic;Bacterial;Parasite;Reactive Oxygen Species
Pathway
– Anti-infection;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
Product type
– Isotope-Labeled Compounds
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
