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Products Details
Product Description
– Dapsone-d4 is the deuterium labeled Dapsone. Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities[1]. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al[2][3].
Web ID
– HY-B0688S1
Shipping
– Room temperature
Molecular Formula
– C12H8D4N2O2S
References
– [1]Y I Zhu, et al. Dapsone and sulfones in dermatology: overview and update. J Am Acad Dermatol|[2]Dapsone, Drug.com|[3]D Voeller, et al. Interaction of Pneumocystis carinii dihydropteroate synthase with sulfonamides and diaminodiphenyl sulfone (dapsone).J Infect Dis. 1994 Feb;169(2):456-9.|[4]Esther Moreno, et al. Evaluation of Skin Permeation and Retention of Topical Dapsone in Murine Cutaneous Leishmaniasis Lesions.Pharmaceutics. 2019 Nov 13;11(11):607.|[5]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
CAS Number
– 1346602-12-7
Molecular Weight
– 252.33
SMILES
– O=S(C1=C([2H])C([2H])=C(C([2H])=C1[2H])N)(C2=CC=C(C=C2)N)=O
Clinical Information
– No Development Reported
Research Area
– Infection; Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Antibiotic;Bacterial;Isotope-Labeled Compounds;Parasite;Reactive Oxygen Species
Pathway
– Anti-infection;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB;Others
Product type
– Isotope-Labeled Compounds
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