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Products Details
Product Description
– Dapsone-13C12 is the 13C12 labeled Dapsone (HY-B0688). Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al[1][2][3][4][5].
Web ID
– HY-B0688S2
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– 13C12H12N2O2S
References
– [1]D Voeller, et al. Interaction of Pneumocystis carinii dihydropteroate synthase with sulfonamides and diaminodiphenyl sulfone (dapsone).J Infect Dis. 1994 Feb;169(2):456-9.|[2]Dapsone, Drug.com|[3]Esther Moreno, et al. Evaluation of Skin Permeation and Retention of Topical Dapsone in Murine Cutaneous Leishmaniasis Lesions.Pharmaceutics. 2019 Nov 13;11(11):607.|[4]Y I Zhu, et al. Dapsone and sulfones in dermatology: overview and update. J Am Acad Dermatol|[5]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.
CAS Number
– 1632119-29-9
Molecular Weight
– 260.21
SMILES
– O=S([13C]1=[13CH][13CH]=[13C](N)[13CH]=[13CH]1)([13C]2=[13CH][13CH]=[13C](N)[13CH]=[13CH]2)=O
Clinical Information
– No Development Reported
Research Area
– Infection; Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Antibiotic;Bacterial;Isotope-Labeled Compounds;Parasite;Reactive Oxygen Species
Pathway
– Anti-infection;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB;Others
Product type
– Isotope-Labeled Compounds
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
