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Dantrolene
$65 – $270
Products Details
Product Description
– Dantrolene is an orally active, non-competitive glutathione reductase inhibitor with a Ki of 111.6 μM and an IC50 of 52.3 μM. Dantrolene is a ryanodine receptor (RyR) antagonist and Ca2+ signaling stabilizer. Dantrolene is a direct-acting skeletal muscle relaxant. Dantrolene can be used for the research of muscle spasticity, malignant hyperthermia, Huntington’s disease and other neuroleptic malignant syndrome[1][2][3].
Web ID
– HY-12542
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C14H10N4O5
Citations
– J Cell Commun Signal. 2023 Sep 13.|ACS Omega. 2020 Oct 12;5(41):26551-26561.|J Anim Sci Biotechnol. 2022 Feb 11;13(1):9.|Research Square Preprint. 2021 May.|Anim Nutr. 28 September 2021.|Cell Res. 2022 Mar;32(3):288-301.|Front Immunol. 2021 Jul 7;12:688674.
References
– [1]Xi Chen, et al. Dantrolene is neuroprotective in Huntington’s disease transgenic mouse model. Mol Neurodegener. 2011 Nov 25;6:81.|[2]F Zhao, et al. Dantrolene inhibition of ryanodine receptor Ca2+ release channels. Molecular mechanism and isoform selectivity. J Biol Chem. 2001 Apr 27;276(17):13810-6.|[3]Christopher B Sylvester, et al. Dantrolene inhibits lysophosphatidylcholine-induced valve interstitial cell calcific nodule formation via blockade of the ryanodine receptor. Front Cardiovasc Med. 2023 Mar 30:10:1112965.|[4]Benjamin Liou, et al. Modulating ryanodine receptors with dantrolene attenuates neuronopathic phenotype in Gaucher disease mice. Hum Mol Genet. 2016 Dec 1;25(23):5126-5141.
CAS Number
– 7261-97-4
Molecular Weight
– 314.25
Compound Purity
– 98.0
SMILES
– O=C1NC(CN1/N=C/C2=CC=C(C3=CC=C([N+]([O-])=O)C=C3)O2)=O
Clinical Information
– Launched
Research Area
– Inflammation/Immunology; Neurological Disease
Solubility
– DMSO : ≥ 20 mg/mL
Target
– Autophagy;Calcium Channel
Pathway
– Autophagy;Membrane Transporter/Ion Channel;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
