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Danavorexton
$780 – $6,400
Products Details
Product Description
– Danavorexton (TAK-925) is an orexin receptor agonist with brain permeability. Danavorexton induces a physiological pattern of OX2R activation in vitro to wake up sleepy mice and improve sleepiness symptoms[1][2][3][4].
Web ID
– HY-133898
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C21H32N2O5S
References
– [1]International Nonproprietary Names for Pharmaceutical Substances (INN). WHO Drug Information, Vol. 34, No. 2, 2020.|[2]Evans R, et al. Orexin 2 receptor-selective agonist danavorexton (TAK-925) promotes wakefulness in non-human primates and healthy individuals. J Sleep Res. 2023 Oct;32(5):e13878|[3]Ishikawa T, et al. Danavorexton, a selective orexin 2 receptor agonist, provides a symptomatic improvement in a narcolepsy mouse model. Pharmacol Biochem Behav. 2022 Oct;220:173464. |[4]Fujimoto T, et al. Discovery of TAK-925 as a Potent, Selective, and Brain-Penetrant Orexin 2 Receptor Agonist. ACS Med Chem Lett. 2022 Feb 4;13(3):457-462.
CAS Number
– 2114324-48-8
Molecular Weight
– 424.55
Compound Purity
– 98.36
SMILES
– O=C(N1[C@@H](CO[C@H]2CC[C@@H](C3=CC=CC=C3)CC2)[C@@H](NS(=O)(C)=O)CCC1)OC
Clinical Information
– Phase 2
Research Area
– Others
Solubility
– 10 mM in DMSO
Target
– Orexin Receptor (OX Receptor)
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
