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Products Details
Product Description
– D-Leucine-d10 is the deuterium labeled D-Leucine. D-Leucine is a more potent anti-seizure agent than L-leucine. D-leucine potently terminates seizures even after the onset of seizure activity. D-leucine, but not L-leucine, reduces long-term potentiation but had no effect on basal synaptic transmission in vitro[1].
Web ID
– HY-Y0378S
Shipping
– Room temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C6H3D10NO2
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.|[2]Xiaoyu Cao, et al. Combination of PARP Inhibitor and Temozolomide to Suppress Chordoma Progression. J Mol Med (Berl). 2019 Aug;97(8):1183-1193
CAS Number
– 271247-12-2
Molecular Weight
– 141.23
SMILES
– [2H]C([2H])([2H])C(C([2H])([2H])[2H])([2H])C([2H])([2H])[C@](N)([2H])C(O)=O
Clinical Information
– No Development Reported
Solubility
– 10 mM in DMSO
Target
– Endogenous Metabolite, Isotope-Labeled Compounds
Pathway
– Metabolic Enzyme/Protease, Others
Product type
– Isotope-Labeled Compounds
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