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D-AP5
SKU
HY-100714A-1 mg
Category Reference compound
Tags iGluR, Membrane Transporter/Ion Channel;Neuronal Signaling, Neurological Disease
$38 – $805
Products Details
Product Description
– D-AP5 (D-APV) is a selective and competitive NMDA receptor antagonist with a Kd of 1.4 μM. D-AP5 (D-APV) inhibits the glutamate binding site of NMDA receptors[1][2].
Web ID
– HY-100714A
Storage Temperature
– -20°C, 3 years (Powder)
Shipping
– Blue Ice
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C5H12NO5P
References
– [1]R H Evans, et al. The effects of a series of omega-phosphonic alpha-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations. Br J Pharmacol. 1982 Jan;75(1):65-75.|[2]Davis S, et al. The NMDA receptor antagonist D-2-amino-5-phosphonopentanoate (D-AP5) impairs spatial learning and LTP in vivo at intracerebral concentrations comparable to those that block LTP in vitro. J Neurosci. 1992 Jan;12(1):21-34.|[3]Morris RG, et al. N-methyl-d-aspartate receptors, learning and memory: chronic intraventricular infusion of the NMDA receptor antagonist d-AP5 interacts directly with the neural mechanisms of spatial learning. Eur J Neurosci. 2013 Mar;37(5):700-17.
CAS Number
– 79055-68-8
Molecular Weight
– 197.13
Compound Purity
– 98.0
SMILES
– N[C@H](CCCP(O)(O)=O)C(O)=O
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C)|Ethanol : < 1 mg/mL (ultrasonic)|H2O : 27.78 mg/mL (ultrasonic)
Target
– iGluR
Isoform
– NMDA Receptor
Pathway
– Membrane Transporter/Ion Channel;Neuronal Signaling
Product type
– Reference compound
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