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CYP51/PD-L1-IN-3
SKU
HY-156151-Get quote
Category Reference compound
Tags Anti-infection;Immunology/Inflammation;Metabolic Enzyme/Protease, Cytochrome P450;Fungal;PD-1/PD-L1, Infection
Products Details
Product Description
– CYP51/PD-L1-IN-3 (compound L21) is a quinazoline compound with antifungal activity. CYP51/PD-L1-IN-3 is a dual inhibitor of CYP51 (IC50: 0.205 μM) and PD-L1 (IC50: 0.039 μM), which can induce early apoptosis of fungal cells in the cell cycle. CYP51/PD-L1-IN-3 also significantly reduced intracellular IL-2, NLRP3, and NF-κBp65 protein levels, induced mitochondrial damage and ROS accumulation, and ultimately led to fungal lysis and death[1].
Web ID
– HY-156151
Shipping
– Room temperature
Molecular Formula
– C27H28N6O2
References
– [1]Sun B, et al. Design, Synthesis, and Activity Evaluation of Novel Dual-Target Inhibitors with Antifungal and Immunoregulatory Properties. J Med Chem. 2023 Sep 13.. .
Molecular Weight
– 468.55
SMILES
– O=C(C1=NC2=CC=CC=C2C(N3C=NC=C3)=N1)NC4CCN(C(C5=CC=C(C(C)C)C=C5)=O)CC4
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– Cytochrome P450;Fungal;PD-1/PD-L1
Pathway
– Anti-infection;Immunology/Inflammation;Metabolic Enzyme/Protease
Product type
– Reference compound
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