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Products Details
Product Description
– CYP3A4-IN-2 is a specific inhibitor of cytochrome P450 3A4 (CYP3A4) with the IC50 value of 0.055 μM. CYP3A4-IN-2 is a ritonavir analogue with increased hydrophobicity of the R2 side group and stronger inhibitory effect compared to ritonavir. CYP3A4-IN-2 can be used as an antiviral agent and immunosuppressants[1].
Web ID
– HY-150580
Shipping
– Room temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C33H38N4O3S
References
– [1]Eric R Samuels, et al. An increase in side-group hydrophobicity largely improves the potency of ritonavir-like inhibitors of CYP3A4. Bioorg Med Chem. 2020 Mar 15;28(6):115349. doi: 10.1016/j.bmc.2020.115349. Epub 2020 Jan 31.
CAS Number
– 2562383-94-0
Molecular Weight
– 570.74
SMILES
– O=C(OC(C)(C)C)NC(CC1=C2C=CC=CC2=CC=C1)CSCC(NC3=CC=CC=C3)C(NCC4=CC=CN=C4)=O
Clinical Information
– No Development Reported
Research Area
– Cancer; Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Cytochrome P450
Isoform
– CYP3
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
