Download Files:
Cyclapolin 9
$350 – $385
Products Details
Product Description
– Cyclapolin 9 is a potent, selective and ATP-competitive polo-like kinase 1 (PLK1) inhibitor with an IC50 of 500 nM. Cyclapolin 9 is inactive against other kinases[1][2].
Web ID
– HY-15159
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C9H4F3N3O4S
References
– [1]Martin Hennenberg, et al. Inhibition of Prostate Smooth Muscle Contraction by Inhibitors of Polo-Like Kinases. Front Physiol. 2018 Jun 15;9:734.|[2]Campbell McInnes, et al. Inhibitors of Polo-like kinase reveal roles in spindle-pole maintenance. Nat Chem Biol. 2006 Nov;2(11):608-17.
CAS Number
– 40533-25-3
Molecular Weight
– 307.21
Compound Purity
– 99.16
SMILES
– O=C(C1=[N+]([O-])C2=CC(C(F)(F)F)=CC([N+]([O-])=O)=C2S1)N
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 20 mg/mL (ultrasonic;warming;heat to 80°C)
Target
– Polo-like Kinase (PLK)
Isoform
– PLK1
Pathway
– Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
