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Products Details
Product Description
– CXCR4 antagonist 6 (compound 46) is a potent CXCR4 antagonist with an IC50 value of 79 nM. CXCR4 antagonist 6 inhibits CXCL12 induced cytosolic calcium flux (IC50 = 0.25 nM). CXCR4 antagonist 6 significantly mitigates CXCL12/CXCR4 mediated cell migration. CXCR4 antagonist 6 exhibits marked efficacy in a cancer metastasis model in mice[1].
Web ID
– HY-146401
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C21H30N6
References
– [1]Li Z, et al. Design, synthesis, and evaluation of pyrrolidine based CXCR4 antagonists with in vivo anti-tumor metastatic activity. Eur J Med Chem. 2020;205:112537.
CAS Number
– 2304750-68-1
Molecular Weight
– 366.50
SMILES
– CC1=CC=CN=C1[C@@H]2CCCN2CC3=NC(C)=NC(N4CCN(CC4)C)=C3
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– CXCR
Isoform
– CXCR4
Pathway
– GPCR/G Protein;Immunology/Inflammation
Product type
– Reference compound
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