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Products Details
Product Description
– CT-721 is a potent and time-dependent Bcr-Abl kinase inhibitor with an IC50 of 21.3 nM for wild-type Bcr-Abl kinase, and possesses anti-chronic myeloid leukemia (CML) activities[1]. CT-721 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Web ID
– HY-108704
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C30H29ClN6O
References
– [1]Sun Y, et al. CT-721, a Potent Bcr-Abl Inhibitor, Exhibits Excellent In Vitro and In Vivo Efficacy in the Treatment of Chronic Myeloid Leukemia. J Cancer. 2017 Aug 23;8(14):2774-2784.
CAS Number
– 1388710-60-8
Molecular Weight
– 525.04
SMILES
– CC1=CC=C(NC(C2=CC=C([C@@H](N3CCN(C)CC3)CC4)C4=C2)=O)C=C1C#CC5=CN=C6N5N=C(Cl)C=C6
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Bcr-Abl
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
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