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Products Details
Product Description
– CSRM617 is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor) with a Kd of 7.43 uM in SPR assays, binding to OC2-HOX domain directly. CSRM617 induces apoptosis by appearance of cleaved Caspase-3 and PARP. CSRM617 is well tolerated in the prostate cancer mouse model[1]
Web ID
– HY-122611
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C10H13N3O5
References
– [1]Rotinen M, et al. ONECUT2 is a targetable master regulator of lethal prostate cancer that suppresses the androgen axis. Nat Med. 2018 Dec;24(12):1887-1898.
CAS Number
– 787504-88-5
Molecular Weight
– 255.23
SMILES
– O=C(C(CO)N)N/N=C/C1=CC=C(C(O)=C1O)O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Androgen Receptor;Apoptosis
Pathway
– Apoptosis;Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
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