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Product Description
– CRTh2 antagonist 3 is a potent chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTh2) antagonist[1]. CRTh2 antagonist 3 enhances the activity of PDK1 toward a short peptide substrate, with an EC50 of 2 μM and a Kd of 8.4 μM. CRTh2 antagonist 3 has the potential for cardiovascular inflammation[2].
Web ID
– HY-135773
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C19H20N2O3S
References
– [1]Heinz Fretz, et al. 2-sulfanyl-benzoimidazol-1-yi-acetic acid derivatives as CRTH2 antagonists. US8273740B2.|[2]Rettenmaier TJ, et al. Small-Molecule Allosteric Modulators of the Protein Kinase PDK1 from Structure-Based Docking. J Med Chem. 2015 Oct 22;58(20):8285-8291.
CAS Number
– 312928-72-6
Molecular Weight
– 356.44
SMILES
– O=C(O)CN1C2=CC=CC=C2N=C1SCCOC3=C(C)C=CC=C3C
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology; Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– PDK-1;Prostaglandin Receptor
Pathway
– GPCR/G Protein;PI3K/Akt/mTOR
Product type
– Reference compound
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