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CRT0066854

$160 – $1,500

Size10 mg

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Products Details

Product Description

– CRT0066854 is a potent and selective atypical PKC isoenzymes inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II kinases with IC50 values of 132 nM, 639 nM, and 620 nM, respectively[1].

Web ID

– HY-18713

Storage Temperature

– -20°C, 3 years; 4°C, 2 years (Powder)

Shipping

– Room Temperature

Applications

– COVID-19-anti-virus

Molecular Formula

– C24H25N5S

References

– [1]Kjær S, et al. Adenosine-binding motif mimicry and cellular effects of a thieno[2,3-d]pyrimidine-based chemical inhibitor of atypical protein kinase C isoenzymes. Biochem J. 2013 Apr 15;451(2):329-42.

CAS Number

– 1438881-19-6

Molecular Weight

– 415.55

Compound Purity

– 99.59

SMILES

– N[C@H](CNC1=NC(C2=CC=NC=C2)=NC3=C1C(CCCC4)=C4S3)CC5=CC=CC=C5

Clinical Information

– No Development Reported

Research Area

– Inflammation/Immunology; Neurological Disease

Solubility

– DMSO : 50 mg/mL (ultrasonic)

Target

– PKC;ROCK

Isoform

– PKCζ;PKC-ι ℩;ROCK2

Pathway

– Cell Cycle/DNA Damage;Cytoskeleton;Epigenetics;Stem Cell/Wnt;TGF-beta/Smad

Product type

– Reference compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.