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Products Details
Product Description
– CRM1-IN-2 (Compound KL2) is a noncovalent CRM1 inhibitor. CRM1-IN-2 localizes CRM1 in the nuclear periphery, depletes nuclear CRM1, and inhibits CRM1-mediated nuclear export. CRM1-IN-2 inhibits growth of colorectal cancer cells, and induces apoptosis[1].
Web ID
– HY-155972A
Shipping
– Room temperature
Molecular Formula
– C29H48N2O5
References
– [1]Jian L,et al. Discovery of Aminoratjadone Derivatives as Potent Noncovalent CRM1 Inhibitors. J Med Chem. 2023 Aug 18.
Molecular Weight
– 504.70
SMILES
– [H][C@]1([C@@H](N)/C=C/C=C(C)/C[C@@H](C)/C=C(C=C[C@@]([H])(C[C@H](N)CC(OC)=O)O)C)O[C@@]([H])(/C=C/C)[C@@H](C)[C@@H](O)C1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;CRM1
Pathway
– Apoptosis;Membrane Transporter/Ion Channel
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
