Download Files:
Products Details
Product Description
– CRK12-IN-1 is a potent CRK12 inhibitor. CRK12-IN-1 is extremely potent against T.b. brucei and rapidly cytocidal, as well as equally potent against T. congolense and T. vivax (EC50 of 1.3 and 18 nM, respectively)[1].
Web ID
– HY-145812
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C20H26F2N4O3S2
References
– [1]Smith A, et al. Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis [published online ahead of print, 2022 Mar 18]. J Med Chem. 2022;10.1021/acs.jmedchem.1c02104.
CAS Number
– 1990479-14-5
Molecular Weight
– 472.57
SMILES
– O=S(N[C@@H]1CC[C@@H](NC2=NC(N)=C(C(C3=C(F)C=CC=C3F)=O)S2)CC1)(CC(C)C)=O
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– Parasite
Isoform
– Trypanosoma
Pathway
– Anti-infection
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
