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Products Details
Product Description
– CP-544439 is a potent and orally active matrix metalloproteinase-13 (MMP-13) inhibitor with an IC50 of 0.75 nM[1][2].
Web ID
– HY-107013
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C18H19FN2O6S
References
– [1]Dalvie D, et al. Metabolism distribution and excretion of a matrix metalloproteinase-13 inhibitor, 4-[4-(4-fluorophenoxy)-benzenesulfonylamino]tetrahydropyran-4-carboxylic acid hydroxyamide (CP-544439), in rats and dogs: assessment of the metabolic profile of CP-544439 in plasma and urine of humans. Drug Metab Dispos. 2008;36(9):1869-1883.|[2]Reiter LA, et al. Pyran-containing sulfonamide hydroxamic acids: potent MMP inhibitors that spare MMP-1. Bioorg Med Chem Lett. 2004;14(13):3389-3395.
CAS Number
– 230954-09-3
Molecular Weight
– 410.42
SMILES
– O=C(NO)C1(CCOCC1)NS(=O)(C2=CC=C(C=C2)OC3=CC=C(C=C3)F)=O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– MMP
Isoform
– MMP-1;MMP-12;MMP-13;MMP-14;MMP-2;MMP-3;MMP-8;MMP-9
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
