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Products Details
Product Description
– COX-2/sEH-IN-1 (Compound 9c) is an orally active, dual COX-2 and sEH (soluble epoxide hydrolase) inhibitor with IC50 values of 1.24 µM and 0.40 nM against COX-2 and sEH, respectively. COX-2/sEH-IN-1 shows improved anti-inflammatory activity and highly reduced cardiovascular risks[1].
Web ID
– HY-146704
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C23H18F3N5O3S
References
– [1]Ahmed H Abdelazeem, et al. Discovery of novel urea-diarylpyrazole hybrids as dual COX-2/sEH inhibitors with improved anti-inflammatory activity and highly reduced cardiovascular risks. Eur J Med Chem. 2020 Nov 1;205:112662.
CAS Number
– 2474977-38-1
Molecular Weight
– 501.48
SMILES
– NS(=O)(C1=CC=C(C=C1)N2N=C(C=C2C3=CC=CC=C3)NC(NC4=CC=C(C=C4)C(F)(F)F)=O)=O
Clinical Information
– No Development Reported
Research Area
– Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– COX;Epoxide Hydrolase
Isoform
– COX-1;COX-2
Pathway
– Immunology/Inflammation;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
