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Products Details
Product Description
– COX-2-IN-30 is a benzenesulfonamide derivative, as well as an orally active and dual inhibitor of COX (IC50=49 nM for COX-2, 10.4 μM for COX-1) and 5-LOX (IC50=2.4 μM). COX-2-IN-30 also inhibits transmembrane hCA IX and hCA XII isoform with nanomolar calss Ki values. COX-2-IN-30 exhibits analgesic, anti-inflammatory, and ulcerogenic activities, and does not show acute gastric effect[1].
Web ID
– HY-149269
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C17H16N6O3S
References
– [1]Ragab MA, et al. 4-(5-Amino-pyrazol-1-yl)benzenesulfonamide derivatives as novel multi-target anti-inflammatory agents endowed with inhibitory activity against COX-2, 5-LOX and carbonic anhydrase: Design, synthesis, and biological assessments. Eur J Med Chem. 2023 Mar 15;250:115180.
CAS Number
– 1160498-08-7
Molecular Weight
– 384.41
SMILES
– O=C(C1=C(N(N=C1)C2=CC=C(C=C2)S(N)(=O)=O)N)N/N=C/C3=CC=CC=C3
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Carbonic Anhydrase;COX;LOX-1
Isoform
– CA â…¡;CA â…¨;CA I;CA XII;COX-1;COX-2
Pathway
– Immunology/Inflammation;Metabolic Enzyme/Protease
Product type
– Reference compound
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