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Products Details
Product Description
– COX-2-IN-22 (Compound 4h) is a COX-2 inhibitor with an IC50 of 8.6 µM. COX-2-IN-22 also inhibits AChE, BChE, β-Secretase, LOX-5 and DPPH with IC50 values of 2.8, 6.3, 15.3, 13.9 and 6.8 µM, respectively. COX-2-IN-22 can cross BBB[1].
Web ID
– HY-147870
Shipping
– Room temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C29H24O7
References
– [1]Agbo EN, et al. Synthesis of furocoumarin-stilbene hybrids as potential multifunctional drugs against multiple biochemical targets associated with Alzheimer’s disease. Bioorg Chem. 2020 Aug;101:103997.
CAS Number
– 2447589-08-2
Molecular Weight
– 484.50
SMILES
– O=C1C=C(/C=C/C2=CC(OC)=CC(OC)=C2)C3=C(C4=C(OC(C5=CC(OC)=CC(OC)=C5)=C4)C=C3)O1
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology; Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Beta-secretase;Cholinesterase (ChE);COX
Isoform
– AChE;BChE;COX-2
Pathway
– Immunology/Inflammation;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
