Products Details

Product Description

– COX-2/5-LOX-IN-3 (compound 5b) is a potent and dual COX-2/5-LOX inhibitor with IC50 values of 45.73, 5.45 and 4.33 μM for COX-1, COX-2, and 5-LOX, respectively. COX-2/5-LOX-IN-3 has the potential for the research of inflammation diseases[1].

Web ID

– HY-147951

Shipping

– Room temperature

Applications

– COVID-19-immunoregulation

Molecular Formula

– C17H16ClN3O2S

References

– [1]Qandeel NA, et al. Synthesis, in vivo anti-inflammatory, COX-1/COX-2 and 5-LOX inhibitory activities of new 2,3,4-trisubstituted thiophene derivatives. Bioorg Chem. 2020 Sep;102:103890.

CAS Number

– 2481484-51-7

Molecular Weight

– 361.85

SMILES

– O=C(NC1=C(C#N)C(C2=CC=C(Cl)C=C2)=CS1)CN3CCOCC3

Clinical Information

– No Development Reported

Research Area

– Inflammation/Immunology

Solubility

– 10 mM in DMSO

Target

– COX;Lipoxygenase

Isoform

– 5-LOX;COX-1;COX-2

Pathway

– Immunology/Inflammation;Metabolic Enzyme/Protease

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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