Download Files:
Products Details
Product Description
– COX-2/15-LOX-IN-1 (Compound 14) is a COX-2 and 15-lipoxygenase enzyme (15-LOX) inhibitor with IC50 values of 10.65, 0.075 and 2.98 μM against COX-1, COX-2 and 15-LOX, respectively. COX-2/15-LOX-IN-1 shows anti-inflammatory activity[1].
Web ID
– HY-150548
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C21H21N7S3
References
– [1]Maghraby MT, et al. Novel class of benzimidazole-thiazole hybrids: The privileged scaffolds of potent anti-inflammatory activity with dual inhibition of cyclooxygenase and 15-lipoxygenase enzymes. Bioorg Med Chem. 2020 Apr 1;28(7):115403.
CAS Number
– 2413565-15-6
Molecular Weight
– 467.63
SMILES
– S=C(NC1=CC=CC=C1)N/N=C(C)/CNC2=NC(N3C(SC)=NC4=CC=CC=C34)=CS2
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– COX;Lipoxygenase
Isoform
– 15-LOX;COX-1;COX-2
Pathway
– Immunology/Inflammation;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
