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Corynoline
$60 – $180
Products Details
Product Description
– Corynoline is a reversible and noncompetitive acetylcholinesterase (AChE) inhibitor with an IC50 of 30.6 μM[1]. Corynoline exhibits anti-inflammatory activity by activating Nrf2[2].
Web ID
– HY-N0826
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C21H21NO5
References
– [1]Kim DK. Inhibitory effect of corynoline isolated from the aerial parts of Corydalis incisa on the acetylcholinesterase. Arch Pharm Res. 2002 Dec;25(6):817-9.|[2]Liu B, et al. Corynoline Exhibits Anti-inflammatory Effects in Lipopolysaccharide (LPS)-Stimulated Human Umbilical Vein Endothelial Cells through Activating Nrf2. Inflammation. 2018 Oct;41(5):1640-1647.
CAS Number
– 18797-79-0
Molecular Weight
– 367.40
Compound Purity
– 99.12
SMILES
– C[C@@]1(C(C=CC2=C3OCO2)=C3CN4C)[C@@]4([H])C(C=C(OCO5)C5=C6)=C6C[C@@H]1O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology; Neurological Disease; Cancer
Solubility
– DMSO : 41.67 mg/mL (ultrasonic)
Target
– Cholinesterase (ChE);Keap1-Nrf2
Isoform
– AChE
Pathway
– Neuronal Signaling;NF-κB
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
