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CORM-3
$25 – $81
Products Details
Product Description
– CORM-3, a carbon monoxide-releasing molecule, attenuates NF-κB p65 nuclear translocation, reduces ROS generation and enhances intracellular glutathione and superoxide dismutase levels. CORM-3 reduces NLRP3 inflammasome activation[1][2][3].
Web ID
– HY-100581
Storage Temperature
– -20°C, 3 years (Powder)
Shipping
– Blue Ice
Applications
– COVID-19-immunoregulation
Molecular Formula
– C5H4ClNO5Ru
References
– [1]Foresti R, et al. Vasoactive properties of CORM-3, a novel water-soluble carbon monoxide-releasing molecule. Br J Pharmacol. 2004 Jun;142(3):453-60.|[2]Lee DW, et al. Carbon monoxide regulates glycolysis-dependent NLRP3 inflammasome activation in macrophages. Biochem Biophys Res Commun. 2017 Nov 18;493(2):957-963.|[3]Huang Y, et al. Carbon monoxide (CO) inhibits hydrogen peroxide (H2O2)-induced oxidative stress and the activation of NF-κB signaling in lens epithelial cells. Exp Eye Res. 2018 Jan;166:29-39.
CAS Number
– 475473-26-8
Molecular Weight
– 294.61
Compound Purity
– 97.0
SMILES
– O#C[Ru+2](C#O)([Cl-])([O-]C1=O)([N]([H])([H])C1)C#O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– |DMSO : 75 mg/mL (ultrasonic)
Target
– NF-κB;NOD-like Receptor (NLR)
Isoform
– NLRP3
Pathway
– Immunology/Inflammation;NF-κB
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
