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Conessine
$130 – $200
Products Details
Product Description
– Conessine, a steroidal alkaloid, is a potent and selective histamine H3 receptor antagonist with Kis of 5.4, 6.0, 5.7 and 25 nM for human, dog, guinea pig, and rat H H3 receptor, respectively. Anti-malarial activity[1].
Web ID
– HY-107566
Storage Temperature
– -20°C (Powder, sealed storage, away from moisture and light)
Shipping
– Blue Ice
Applications
– COVID-19-immunoregulation
Molecular Formula
– C24H40N2
References
– [1]Santora VJ, et al. A new family of H3 receptor antagonists based on the natural product Conessine. Bioorg Med Chem Lett. 2008;18(4):1490-1494.|[2]Kim H, et al. Conessine treatment reduces dexamethasone-induced muscle atrophy by regulating MuRF1 and atrogin-1 expression [published online ahead of print, 2018 Feb 1]. J Microbiol Biotechnol. 2018;10.4014.jmb.1711.11009.
CAS Number
– 546-06-5
Molecular Weight
– 356.59
Compound Purity
– 98.0
SMILES
– C[C@H]1[C@]2([H])[C@]3(CN1C)[C@](CC2)([H])[C@@]4([H])[C@]([C@@]5(C(C[C@H](CC5)N(C)C)=CC4)C)([H])CC3
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– Ethanol : 25 mg/mL (ultrasonic)
Target
– Histamine Receptor;Parasite
Isoform
– H3 Receptor;Plasmodium
Pathway
– Anti-infection;GPCR/G Protein;Immunology/Inflammation;Neuronal Signaling
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
