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Products Details
Product Description
– Condurango glycoside A is an activator of p53. Condurango glycoside A initiates ROS generation and up-regulates p53 expression. Condurango glycoside A induces apoptosis and pre-mature senescence associated with DNA damage in HeLa cells[1].
Web ID
– HY-N12233
Shipping
– Room temperature
Molecular Formula
– C53H78O17
References
– [1]Bishayee K, et al. Condurango-glycoside-A fraction of Gonolobus condurango induces DNA damage associated senescence and apoptosis via ROS-dependent p53 signalling pathway in HeLa cells. Mol Cell Biochem. 2013 Oct;382(1-2):173-83.
CAS Number
– 11051-90-4
Molecular Weight
– 987.18
SMILES
– C[C@@H]1[C@@H](O)[C@@H](OC)[C@@H](O)[C@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](C)O[C@@H](O[C@H]4CC[C@@]5(C)C(CCC6C5[C@H](OC(C)=O)[C@@H](OC(/C=C/C7=CC=CC=C7)=O)[C@@]8(C)[C@]6(O)CC[C@@H]8C(C)=O)C4)C[C@@H]3OC)C[C@@H]2OC)O1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;MDM-2/p53;Reactive Oxygen Species
Pathway
– Apoptosis;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
Product type
– Reference compound
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