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Cofrogliptin
$350 – $2,900
Products Details
Product Description
– Cofrogliptin (HSK7653) (compound 2), a tetrahydropyran derivative, is a potent oral dipeptidyl aminopeptidase 4 (DPP-4) inhibitor with Long-acting antidiabetic efficacy. Cofrogliptin (compound 2) has a great potential for type 2 diabetes mellitus (T2DM) [1].
Web ID
– HY-147257
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C18H19F5N4O3S
References
– [1]International Nonproprietary Names for Pharmaceutical Substances (INN)|[2]Chen Zhang, et al. Design, Synthesis, and Evaluation of a Series of Novel Super Long-Acting DPP-4 Inhibitors for the Treatment of Type 2 Diabetes. J Med Chem. 2020 Jul 9;63(13):7108-7126.
CAS Number
– 1844874-26-5
Molecular Weight
– 466.43
Compound Purity
– 99.07
SMILES
– FC(F)([C@@H](O[C@]1([H])C(C=C2F)=C(C=C2)F)[C@@](N(CC3=N4)CC3=CN4[S](C)(=O)=O)([H])C[C@@H]1N)F
Clinical Information
– Phase 3
Research Area
– Metabolic Disease
Solubility
– DMSO : 100 mg/mL (ultrasonic)
Target
– Dipeptidyl Peptidase
Isoform
– DPP-4
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
