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Products Details
Product Description
– CNBCA is a potent, selective, competitive SHP2 enzyme inhibitor, with the IC50 of 0.87 μM. CNBCA binds to full-length SHP2 and inhibits enzyme activity. CNBCA inhibits pAkt and pERK1/2, and the cell growth of BT474 and MDA-MB468 cells. CNBCA can be used for breast cancer study[1].
Web ID
– HY-155098
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C26H34O5
References
– [1]Dhanaji M, et al. Targeting SHP2 with an Active Site Inhibitor Blocks Signaling and Breast Cancer Cell Phenotypes. ACS Bio Med Chem Au 2023
Molecular Weight
– 426.55
SMILES
– OC(CCCC1=C(OCCCCCCCCC)C=CC(C2=CC=C(C(O)=O)C=C2)=C1)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– SHP2
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
