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CMS-121
$35 – $480
Products Details
Product Description
– CMS-121 is a quinolone derivative and an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor. CMS-121 protects HT22 cells against ischemia and oxidative damage with EC50 values of 7 nM and 200 nM, respectively. CMS-121 has strong neuroprotective, anti-inflammatory, antioxidative and renoprotective activities[1][2][3].
Web ID
– HY-135981
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C20H19NO3
References
– [1]Currais A, et al. Elevating acetyl-CoA levels reduces aspects of brain aging. Elife. 2019 Nov 19;8. pii: e47866.|[2]Chiruta C, et al. Chemical modification of the multitarget neuroprotective compound fisetin. J Med Chem. 2012 Jan 12;55(1):378-89.|[3]Prior M, et al. Back to the future with phenotypic screening. ACS Chem Neurosci. 2014 Jul 16;5(7):503-13.
CAS Number
– 1353224-53-9
Molecular Weight
– 321.37
Compound Purity
– 99.63
SMILES
– OC1=CC=C(C2=NC3=CC=CC=C3C(OC4CCCC4)=C2)C=C1O
Clinical Information
– Phase 1
Research Area
– Inflammation/Immunology; Neurological Disease
Solubility
– DMSO : 50 mg/mL (ultrasonic)
Target
– Acetyl-CoA Carboxylase
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
