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Product Description
– CMP-Sialic acid (CMP-Neu5Ac) is an allosteric inhibitor of UDP-GlcNAc 2-epimerase. CMP-Sialic acid provides a substrate for Golgi sialyltransferases. CMP-Sialic acid is an important sugar nucleotide for biosynthesis of sialic acid and its conjugates[1].
Web ID
– HY-112942
Shipping
– Room temperature
Molecular Formula
– C20H31N4O16P
References
– [1]Münster AK, et al. Mammalian cytidine 5′-monophosphate N-acetylneuraminic acid synthetase: a nuclear protein with evolutionarily conserved structural motifs. Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9140-5.|[2]Jing Song, et al. Reassembled Biosynthetic Pathway for a Large-scale Synthesis of CMP-Neu5Ac. Mar Drugs. 2003 Dec; 1(4): 34-45.|[3]Mercado CP, et al. A serotonin-induced N-glycan switch regulates platelet aggregation. Sci Rep. 2013 Sep 30;3:2795.
CAS Number
– 3063-71-6
Molecular Weight
– 614.45
SMILES
– O[C@@H]1[C@H](O[C@@H](N2C(N=C(N)C=C2)=O)[C@@H]1O)COP(O[C@@]3(O[C@@]([C@H](NC(C)=O)[C@@H](O)C3)([H])[C@H](O)[C@H](O)CO)C(O)=O)(O)=O
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– 10 mM in DMSO
Target
– Endogenous Metabolite
Isoform
– Human Endogenous Metabolite
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
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