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CM03
$300 – $2,250
Products Details
Product Description
– CM03 is a potent DNA G-quadruplexes (G4s) ligand. CM03 can stabilise G4s, downregulating more G4-containing genes as well as increasing incidence of double-strand break events (DSBs) due to torsional strain on DNA and chromatin structure. CM03 has selective potency for pancreatic cancer cells[1][2].
Web ID
– HY-121862
Storage Temperature
– -20°C, 3 years (Powder)
Shipping
– Blue Ice
Applications
– Cancer-programmed cell death
Molecular Formula
– C34H44N6O6
References
– [1]Ahmed AA, et al. A G-Quadruplex-Binding Small Molecule and the HDAC Inhibitor SAHA (Vorinostat) Act Synergistically in Gemcitabine-Sensitive and Resistant Pancreatic Cancer Cells. Molecules. 2020 Nov 19;25(22):5407.|[2]Ahmed AA, et al. Asymmetrically Substituted Quadruplex-Binding Naphthalene Diimide Showing Potent Activity in Pancreatic Cancer Models. ACS Med Chem Lett. 2020 Jul 16;11(8):1634-1644.
CAS Number
– 2101208-44-8
Molecular Weight
– 632.75
Compound Purity
– 99.73
SMILES
– O=C(C1=CC=C2C3=O)N(C(C4=C1C2=C(C=C4NCCN5CCCC5)C(N3CCCN6CCOCC6)=O)=O)CCCN7CCOCC7
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 2 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– DNA/RNA Synthesis
Pathway
– Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
