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Products Details
Product Description
– Closantel-13C6 is the 13C6 labeled Closantel. Closantel is a halogenated salicylanilide with a potent anti-parasitic activity. Closantel is a potent and highly specific Onchocerca volvulus chitinase (OvCHT1) inhibitor with an IC50 of 1.6 μM and a Ki of 468 nM. Closantel inhibits the O. volvulus L3 to L4 molt of developing.
Web ID
– HY-17596S
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C16 13C6H14Cl2I2N2O2
References
– [1]Amanda L Garner, et al. Design, synthesis, and biological activities of closantel analogues: structural promiscuity and its impact on Onchocerca volvulus. J Med Chem. 2011 Jun 9;54(11):3963-72.|[2]Amanda L Garner, et al. Design, synthesis, and biological activities of closantel analogues: structural promiscuity and its impact on Onchocerca volvulus. J Med Chem. 2011 Jun 9;54(11):3963-72.|[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.
CAS Number
– 1325559-20-3
Molecular Weight
– 669.03
SMILES
– N#CC(C(C=C1)=CC=C1Cl)C(C=C2C)=C(C=C2NC([13C]([13CH]=[13C]3I)=[13C]([13C](I)=[13CH]3)O)=O)Cl
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– Isotope-Labeled Compounds;Parasite
Pathway
– Anti-infection;Others
Product type
– Isotope-Labeled Compounds
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
