Clonidine (hydrochloride)

$66$185

Products Details

Product Description

– Clonidine hydrochloride is an agonist of α2-adrenoceptor and potent antihypertensive agent.

Web ID

– HY-B0409A

Storage Temperature

– 4°C (Powder, sealed storage, away from moisture)

Shipping

– Room Temperature

Applications

– COVID-19-immunoregulation

Molecular Formula

– C9H10Cl3N3

References

– [1]Bugajski J, et al. The involvement of central alpha-adrenergic and histamine H2-receptors in the hypothermia induced by clonidine in the rat. Neuropharmacology. 1980 Jan;19(1):9-15.|[2]Zhang YM, et al. Clonidine induces calcitonin gene-related peptide expression via nitric oxide pathway in endothelial cells. Peptides. 2009 Sep;30(9):1746-52.|[3]Jentsch JD, et al. Clonidine and guanfacine attenuate phencyclidine-induced dopamine overflow in rat prefrontal cortex: mediating influence of the alpha-2A adrenoceptor subtype. Brain Res. 2008 Dec 30;1246:41-6.|[4]Nassar N, et al. Brainstem adenosine A1 receptor signaling masks phosphorylated extracellular signal-regulated kinase 1/2-dependent hypotensive action of clonidine in conscious normotensive rats. J Pharmacol Exp Ther. 2009 Jan;328(1):83-9.

CAS Number

– 4205-91-8

Molecular Weight

– 266.55

Compound Purity

– 99.96

SMILES

– ClC1=C(NC2=NCCN2)C(Cl)=CC=C1.Cl

Clinical Information

– Launched

Research Area

– Cardiovascular Disease; Endocrinology; Cancer

Solubility

– DMSO : 7.6 mg/mL (ultrasonic;warming)|H2O : 33.33 mg/mL (ultrasonic)

Target

– Adrenergic Receptor

Isoform

– α adrenergic receptor

Pathway

– GPCR/G Protein;Neuronal Signaling

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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