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Clonidine (hydrochloride)
$66 – $185
Products Details
Product Description
– Clonidine hydrochloride is an agonist of α2-adrenoceptor and potent antihypertensive agent.
Web ID
– HY-B0409A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C9H10Cl3N3
References
– [1]Bugajski J, et al. The involvement of central alpha-adrenergic and histamine H2-receptors in the hypothermia induced by clonidine in the rat. Neuropharmacology. 1980 Jan;19(1):9-15.|[2]Zhang YM, et al. Clonidine induces calcitonin gene-related peptide expression via nitric oxide pathway in endothelial cells. Peptides. 2009 Sep;30(9):1746-52.|[3]Jentsch JD, et al. Clonidine and guanfacine attenuate phencyclidine-induced dopamine overflow in rat prefrontal cortex: mediating influence of the alpha-2A adrenoceptor subtype. Brain Res. 2008 Dec 30;1246:41-6.|[4]Nassar N, et al. Brainstem adenosine A1 receptor signaling masks phosphorylated extracellular signal-regulated kinase 1/2-dependent hypotensive action of clonidine in conscious normotensive rats. J Pharmacol Exp Ther. 2009 Jan;328(1):83-9.
CAS Number
– 4205-91-8
Molecular Weight
– 266.55
Compound Purity
– 99.96
SMILES
– ClC1=C(NC2=NCCN2)C(Cl)=CC=C1.Cl
Clinical Information
– Launched
Research Area
– Cardiovascular Disease; Endocrinology; Cancer
Solubility
– DMSO : 7.6 mg/mL (ultrasonic;warming)|H2O : 33.33 mg/mL (ultrasonic)
Target
– Adrenergic Receptor
Isoform
– α adrenergic receptor
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
