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Products Details
Product Description
– Clofibrate-d4 is the deuterium labeled Clofibrate. Clofibrate is an agonist of PPAR, with EC50s of 50 μM, ∼500 μM for murine PPARα and PPARγ, and 55 μM, ∼500 μM for human PPARα and PPARγ, respectively.
Web ID
– HY-B0287S
Shipping
– Room temperature
Molecular Formula
– C12H11D4ClO3
References
– [1]Chen SH, et al. Prenatal PPARα activation by clofibrate increases subcutaneous fat browning in male C57BL/6J mice fed a high-fat diet during adulthood. PLoS One. 2017 Nov 2;12(11):e0187507.|[2]Willson TM, et al. The PPARs: from orphan receptors to drug discovery. J Med Chem. 2000 Feb 24;43(4):527-50.|[3]Chen Y, et al. Clofibrate Attenuates ROS Production by Lipid Overload in Cultured Rat Hepatoma Cells. J Pharm Pharm Sci. 2017;20(0):239-251.|[4]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
CAS Number
– 1189654-03-2
Molecular Weight
– 246.72
SMILES
– CCOC(C(C)(C)OC1=C([2H])C([2H])=C(C([2H])=C1[2H])Cl)=O
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– 10 mM in DMSO
Target
– Isotope-Labeled Compounds;PPAR
Pathway
– Cell Cycle/DNA Damage;Others;Vitamin D Related/Nuclear Receptor
Product type
– Isotope-Labeled Compounds
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