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CLK8
$170 – $1,700
Products Details
Product Description
– CLK8 is a potent and specific CLOCK inhibitor that can disrupt the interaction between CLOCK and BMAL1 and interfere with nuclear translocation of CLOCK. CLK8 can be used for the research of disorders associated with dampened circadian rhythms[1].
Web ID
– HY-148765
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture and light)
Shipping
– Room Temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C29H26N2O6
References
– [1]Doruk YU, et, al. A CLOCK-binding small molecule disrupts the interaction between CLOCK and BMAL1 and enhances circadian rhythm amplitude. J Biol Chem. 2020 Mar 13;295(11):3518-3531.
CAS Number
– 898920-65-5
Molecular Weight
– 498.53
Compound Purity
– 98.03
SMILES
– O=C(COC1=C(C(C2=CC=CC=C2)=CC(O3)=O)C3=C(CCC(C)(C)O4)C4=C1)NC5=C(C(N)=O)C=CC=C5
Clinical Information
– No Development Reported
Research Area
– Cancer; Metabolic Disease
Solubility
– DMSO : 50 mg/mL (ultrasonic)
Target
– Cryptochrome
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
