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Clemizole (hydrochloride)
$50 – $480
Products Details
Product Description
– Clemizole hydrochloride is an H1 histamine receptor antagonist, is found to substantially inhibit HCV replication. Clemizole hydrochloride is an inhibitor of TRPC5 channel. The IC50 of Clemizole hydrochloride for RNA binding by NS4B is 24 nM, whereas its EC50 for viral replication is 8 µM.
Web ID
– HY-30234A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C19H21Cl2N3
References
– [1]Nishimura T, et al. Using chimeric mice with humanized livers to predict human drug metabolism and a drug-drug interaction. J Pharmacol Exp Ther. 2013 Feb;344(2):388-96.|[2]Richter JM, et al. Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5. Mol Pharmacol. 2014 Nov;86(5):514-21|[3]Einav S, et al. Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis. Nat Biotechnol. 2008 Sep;26(9):1019-27
CAS Number
– 1163-36-6
Molecular Weight
– 362.30
Compound Purity
– 99.99
SMILES
– ClC1=CC=C(C=C1)CN2C(CN3CCCC3)=NC4=CC=CC=C24.[H]Cl
Clinical Information
– Launched
Research Area
– Cancer; Inflammation/Immunology; Endocrinology
Solubility
– DMSO : 33.33 mg/mL (ultrasonic)|H2O : 20 mg/mL (ultrasonic)
Target
– HCV;HCV Protease;Histamine Receptor;TRP Channel
Isoform
– H1 Receptor
Pathway
– Anti-infection;GPCR/G Protein;Immunology/Inflammation;Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
