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Products Details
Product Description
– Clemastine-d5 (fumarate) is the deuterium labeled Clemastine fumarate. Clemastine fumarate (HS-592 fumarate) is a selective histamine H1 receptor antagonist with IC50 of 3 nM.
Web ID
– HY-B0298AS
Shipping
– Room temperature
Molecular Formula
– C25H25D5ClNO5
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Seifert, R., et al., Histamine increases cytosolic Ca2+ in dibutyryl-cAMP-differentiated HL-60 cells via H1 receptors and is an incomplete secretagogue. Mol Pharmacol, 1992. 42(2): p. 227-34.|[3]Schran, H.F., et al., The pharmacokinetics and bioavailability of clemastine and phenylpropanolamine in single-component and combination formulations. J Clin Pharmacol, 1996. 36(10): p. 911-22.
Molecular Weight
– 464.99
SMILES
– CN1[C@@H](CCO[C@](C2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])(C3=CC=C(Cl)C=C3)C)CCC1.O=C(O)/C=C/C(O)=O
Clinical Information
– No Development Reported
Research Area
– Neurological Disease; Endocrinology
Solubility
– 10 mM in DMSO
Target
– Autophagy;Histamine Receptor;Isotope-Labeled Compounds
Isoform
– H1 Receptor
Pathway
– Autophagy;GPCR/G Protein;Immunology/Inflammation;Neuronal Signaling;Others
Product type
– Isotope-Labeled Compounds
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
