Download Files:
CLEFMA
$316
Only 1000 item(s) left in stock.
Products Details
Product Description
– CLEFMA is a curcuminoid with antitumor activity. CLEFMA inhibits tumor growth is associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects[1][2].
Web ID
– HY-136718
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C23H17Cl2NO4
References
– [1]Lagisetty P, et, al. CLEFMA-an anti-proliferative curcuminoid from structure-activity relationship studies on 3,5-bis(benzylidene)-4-piperidones. Bioorg Med Chem. 2010 Aug 15; 18(16):6109-20.|[2]Yadav VR, et, al. Preclinical evaluation of 4-[3,5-bis(2-chlorobenzylidene)-4-oxo-piperidine-1-yl]-4-oxo-2-butenoic acid, in a mouse model of lung cancer xenograft. Br J Pharmacol. 2013 Dec; 170(7): 1436-48.
CAS Number
– 1246964-32-8
Molecular Weight
– 442.29
SMILES
– O=C(O)/C=CC(N1C/C(C(/C(C1)=C/C2=CC=CC=C2Cl)=O)=CC3=CC=CC=C3Cl)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis
Pathway
– Apoptosis
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
