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CK-666
$99 – $715
Products Details
Product Description
– CK-666 is a cell-permeable actin-related protein Arp2/3 complex inhibitor (IC50=12 μM). CK-666 binds to Arp2/3 complex, stabilizes the inactive state of the complex, blocking movement of the Arp2 and Arp3 subunits into the activated filament-like (short pitch) conformation[1][2].
Web ID
– HY-16926
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Molecular Formula
– C18H17FN2O
References
– [1]Hetrick B, et al. Small molecules CK-666 and CK-869 inhibit actin-related protein 2/3 complex by blocking an activating conformational change. Chem Biol. 2013 May 23;20(5):701-12.|[2]Brieuc P Perot, et al. Dendritic Cell Maturation Regulates TSPAN7 Function in HIV-1 Transfer to CD4<sup>+</sup> T Lymphocytes. Front Cell Infect Microbiol. 2020 Feb 28;10:70.
CAS Number
– 442633-00-3
Molecular Weight
– 296.34
Compound Purity
– 99.79
SMILES
– O=C(NCCC1=C(C)NC2=C1C=CC=C2)C3=CC=CC=C3F
Clinical Information
– No Development Reported
Research Area
– Cancer; Infection
Solubility
– DMSO : 125 mg/mL (ultrasonic)
Target
– Arp2/3 Complex;HIV
Isoform
– HIV-1
Pathway
– Anti-infection;Cytoskeleton
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
