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cis-α-(Carboxycyclopropyl)glycine
$141
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Products Details
Product Description
– cis-α-(Carboxycyclopropyl)glycine (L-CCG III) is a potent, competitive glutamate uptake inhibitor. cis-α-(Carboxycyclopropyl)glycine is a substrate of glutamate transporters (GluT) (EC50: 13 μM, 2 μM for EAAT 1 and EAAT 2, respectively). cis-α-(Carboxycyclopropyl)glycine inhibits a Na+-dependent high-affinity L-glutamate uptake in glial plasmalemmal vesicles (GPV) and synaptosomes[1][2].
Web ID
– HY-100838
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C6H9NO4
References
– [1]Y Nakamura, et al. (2S,3S,4R)-2-(carboxycyclopropyl)glycine, a potent and competitive inhibitor of both glial and neuronal uptake of glutamate. Neuropharmacology. 1993 Sep;32(9):833-7. |[2]Charbel El-Hajj Moussa, et al. Effects of L-glutamate transport inhibition by a conformationally restricted glutamate analogue (2S,1’S,2’R)-2-(carboxycyclopropyl)glycine (L-CCG III) on metabolism in brain tissue in vitro analysed by NMR spectroscopy. Neurochem Res. 2002 Feb;27(1-2):27-35.
CAS Number
– 117857-95-1
Molecular Weight
– 159.14
SMILES
– [H][C@@]1([C@H](N)C(O)=O)[C@H](C(O)=O)C1
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– EAAT
Isoform
– EAAT1;EAAT2
Pathway
– Membrane Transporter/Ion Channel
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
