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Products Details
Product Description
– cis-BG47 is an cis-isomer of BG47, BG47 is a prototypical histone deacetylases HDAC1 and HDAC2 selective, optoepigenetic probe. BG47 can bind to and competitively inhibits the deacetylase activity of HDAC targets upon a light-induced trans-to-cis isomerization, and increases Histone Methyltransferase H3K9 acetylation. cis-BG47 can be used for neurological disease research[1].
Web ID
– HY-117583
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C25H22N4O2S
References
– [1]Reis SA, et al. Light-controlled modulation of gene expression by chemical optoepigenetic probes. Nat Chem Biol. 2016 May;12(5):317-23.
Molecular Weight
– 442.53
SMILES
– O=C(C1=CC=C(C=C1)/N=NC2=CC=C(C=C2)N(C)C)NC3=CC(C4=CC=CS4)=CC=C3O
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– HDAC;Histone Methyltransferase
Isoform
– HDAC1;HDAC2
Pathway
– Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
